Researchers have discovered a new target towards food allergy treatment announced in the Journal of Allergy and Clinical Immunology.
The finding shows that the level of a small intestine enzyme called “Pim1 kinase” is higher in mice that suffer from peanut allergy. Blocking activity of Pim1 seems to reduce the allergic response to peanuts.
According to recent statistics, around 4% of Americans suffer from food allergy. Symptoms can range from hives, vomiting, difficulty breathing to the severe anaphylaxis. Consuming peanuts, their proteins enter into the bloodstream via the intestines and cause an immune response those who have peanut allergy.
Dr. Erwin Gelfand, chair of pediatrics at National Jewish Health says, “Pim1, and its associated transcription factor, Runx3 mRNA, play a crucial role in allergic reactions to peanuts”.
Dr. Gelfand’s laboratory research has shown that the Pim1 increases upon allergen sensitization and is responsible for the downregulation of Runx3. The study shows in mice that the upregulation of Runx3 can be alter by inhibiting Pim1 kinase. This strategy essentially reduce allergic reaction in mice.
PIM-1 kinase contributes to several signaling pathways and is expressed in T cells and eosinophils, type of cells associated with allergic diseases. Runx3 is linked with the regulation of T cells.
Allergic mice, that consumed peanuts, had increased levels of Pim1 enzyme in their intestines, as well as higher levels of inflammatory cells, and cytokine molecules that are associated to allergies. However, levels of Runx3 were dropped significantly in the allergic mice. When researchers administered a small molecule called AR460770, the activity of PIM-1 kinase was blocked and mice did not experience diarrhea and other peanut allergy related symptoms.
The main culprit of allergic reaction is the enhanced level of histamine in the plasma. After administration of AR460770, made by Array Biophama, the histamine level fell to about baseline levels and Runx3 mRNA increased almost back to baseline levels. Upregulating Runx3 by targeting Pim1 kinase represent a new way for treating allergic diseases.
“Our data identified for the first time that Pim1 kinase contributes in important ways to the development of peanut-induced allergic responses. Targeting this novel regulatory axis involving Pim1 kinase and Runx3 offers new therapeutic opportunities for the control of food-induced allergic reactions.”- said Dr. Gelfand.
- Raising awareness for food allergy is crucial (livingwithallergy.wordpress.com)
- When to Introduce Peanuts to Kids: How to reduce food allergy risk | Babble (babble.com)